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Ken Stuart , Ph.D.

Selected Publications

Panigrahi,A.K., Ernst,N.L., Domingo,G.J., Fleck,M., Salavati,R., and Stuart,K.D. Compositionally and Functionally Distinct Editosomes in Trypanosoma brucei. RNA. 2006. 12, 1038-1049. PMID: 16611942

Salavati,R., Ernst,N.L., O'Rear,J., Gilliam,T., Tarun,S., Jr., and Stuart,K. KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA. 2006. 12, 819-831. PMID: 16601201

Deng,J., Ernst,N.L., Turley,S., Stuart,K.D., and Hol,W.G.J. Structural basis for UTP specificity of RNA Editing TUTases from Trypanosoma brucei. EMBO J. 2005. 24, 4007-4017. PMID: 16281058

Carnes,J., Trotter,J.R., Ernst,N.L., Steinberg,A.G., and Stuart,K. An Essential RNAse III Insertion Editing Endonuclease in Trypanosoma brucei. Proc. Natl. Acad. Sci. U. S. A. 2005. 102: 16614-16619. PMID: 16269544

Trotter JR, Ernst NL, Carnes J, Panicucci B, Stuart K. A Deletion Site Editing Endonuclease in Trypanosoma brucei. 2005. Mol Cell 20: 403-412. PMID: 16285922

Schnaufer A, Clark-Walker GD, Steinberg AG, Stuart K. The F(1)-ATP synthase complex in bloodstream stage trypanosomes has an unusual and essential function. EMBO J 2005. 24: 4029-4040. PMID: 16270030

Vondruskova, E., Van den Burg, J., Zikova, A., Ernst, N. L., Stuart, K., Benne, R., and Lukes, J. RNA interference analyses suggest a transcript-specific regulatory role for MRP1 and MRP2 in RNA editing and other RNA processing in Trypanosoma brucei. J. Biol. Chem. 2005. 280:2429-2438. PMID: 15504736

Martinez-Calvillo, S., Stuart, K., and Myler, P. J. Ploidy changes associated with disruption of two adjacent genes on Leishmania major chromosome 1. Int. J. Parasitol. 2005. 35:419-429. PMID: 15777918

El-Sayed, N.M.A., et al., Stuart, K.D., Hall, N. Comparative genomics of the trypanosomatids. Science. 2005. 309:404-409. PMID: 16020724

El-Sayed, N.M.A., et al., Stuart, K.D., Andersson, B. The genome sequence of Trypanosoma cruzi, etiological agent of Chagas' disease. Science. 2005. 309:409-415. PMID: 16020725

Ivens, A.C., et al., Stuart, K.D., Barrell, B., Myler, P.J. The genome of the kinetoplastid parasite, Leishmania major. Science. 2005. 309:436-442. PMID: 16020728

Brecht,M., Niemann,M., Schlüter,E., Müller,U.F., Stuart,K., Göringer,H.U. TbMP42, a protein component of the RNA editing complex in African trypanosomes has endo-exoribonuclease activity. Mol Cell. 2005. 17:621-630. PMID: 15749013

Inoue,M.,Nakamura,Y., Yasuda,K., Yasaka,N., Hara,T., Schnaufer,A., Stuart,K., Fukuma,T. The 14-3-3 proteins of Trypanosoma brucei function in motility, cytokinesis and cell cycle. J. of Biol. Chem. 2005. 280:14085-14096. PMID: 15653691

Stuart,K.D., Schnaufer,A., Ernst,N.L., Panigrahi,A.K. Complex management: RNA editing in trypanosomes. Trends in Biochemical Sciences. 2005. 30: 97-105. PMID: 15691655

Ghedin, E., et al., Stuart, K., Fraser, C. M., and El-Sayed, N. M. A. Gene synteny and evolution of genome architecture in trypanosomatids. Mol. Biochem. Parasitol. 2004. 134:183-191. PMID: 15003838

Martinez-Calvillo, S., Nguyen, D. T., Stuart, K.D., and Myler, P. J. Transcription initiation and termination on Leishmania major chromosome 3. Eukaryot. Cell 2004. 3:506-517. PMID: 15075279

Stuart, K., Salavati, R., Igo, R.P., Jr., Ernst, N. L., Palazzo, S.S., Wang, B. In vitro assays for kinetoplastid U insertion-deletion, editing and associated enzymatic activities. Methods in Mol Biology. 2004. 265:251-272. PMID: 15103078

Stuart, K., Panigrahi, A.K., Schnaufer, A. Identification and characterization of trypanosome RNA editing complex components. Methods in Molecular Biology. 2004. 265:273-291. PMID: 15103079

Domingo Villegas, G., Palazzo, S., Wang, B., Panicucci, B., Salavati, R. and Stuart, K.D. Dyskinetoplastic Trypanosoma brucei Contains Functional Editing Complexes. Eukaryotic Cell (2003) 2:569-577. PMID: 12796302

Worthey, E. A., Schnaufer, A., Mian, I. S., Stuart, K., and Salavati, R. Comparative analysis of editosome proteins in trypanosomatids. Nucleic Acids Res. 2003. 31:6392-6408. PMID: 14602897

Worthey EA, Martinez-Calvillo S, Schnaufer A, Aggarwal G, Cawthra J, Fazelinia G, Fong C, Fu G, Hassebrock M, Hixson G, Ivens AC, Kiser P, Marsolini F, Rickell E, Salavati R, Sisk E, Sunkin SM, Stuart KD, Myler PJ. Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene. Nucleic Acids Res. 2003 Jul 15;31(14):4201-10. PMID: 12853638

Ernst NL, Panicucci B, Igo RP Jr, Panigrahi AK, Salavati R, Stuart K. TbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosome. Mol Cell. 2003 Jun;11(6):1525-36. PMID: 12820966

Schnaufer A, Ernst NL, Palazzo SS, O'Rear J, Salavati R, Stuart K. Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex. Mol Cell. 2003 Aug;12(2):307-19. PMID: 14536071

Saxena A, Worthey EA, Yan S, Leland A, Stuart KD, Myler PJ. Evaluation of differential gene expression in Leishmania major Friedlin procyclics and metacyclics using DNA microarray analysis. Mol Biochem Parasitol. 2003 Jun;129(1):103-14. PMID: 12798511

Martinez-Calvillo S, Yan S, Nguyen D, Fox M, Stuart K, Myler PJ. Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region. Mol Cell. 2003 May;11(5):1291-9. PMID: 12769852

Wang B, Ernst NL, Palazzo SS, Panigrahi AK, Salavati R, Stuart K. TbMP44 is essential for RNA editing and structural integrity of the editosome in Trypanosoma brucei. Eukaryot Cell. 2003 Jun;2(3):578-87. PMID: 12796303

Panigrahi AK, Allen TE, Stuart K, Haynes PA, Gygi SP. Mass spectrometric analysis of the editosome and other multiprotein complexes in Trypanosoma brucei. J Am Soc Mass Spectrom. 2003 Jul;14(7):728-35. PMID: 12837594

Panigrahi AK, Schnaufer A, Ernst NL, Wang B, Carmean N, Salavati R, Stuart K. Identification of novel components of Trypanosoma brucei editosomes. RNA. 2003 Apr;9(4):484-92. PMID: 12649499

Stuart, K. and Panigrahi, A. RNA editing: complexity and complications. Mol. Microbiol. 2002. 45:591-596. PMID: 12139607

Salavati, R., Panigrahi, A.K., Morach, B., Palazzo, S., Igo, R.P. Jr., and Stuart, K. Endoribonuclease activities of Trypanosoma brucei mitochondria.  Mol. Biochem. Parasitol 2002. 120:23-31. PMID: 11849702

Igo, R.P., Jr., Lawson, S., and Stuart, K. RNA sequence and basepairing effects on insertion editing in T. brucei.   Mol. Cell. Biol. 2002. 22:1567-1576. PMID: 11839822

Igo RP Jr, Weston DS, Ernst NL, Panigrahi AK, Salavati R, Stuart K. Role of uridylate-specific exoribonuclease activity in Trypanosoma brucei RNA editing. Eukaryot Cell. 2002 Feb;1(1):112-8. PMID: 12455977

Drozdz M, Palazzo SS, Salavati R, O'Rear J, Clayton C, Stuart K. TbMP81 is required for RNA editing in Trypanosoma brucei. EMBO J. 2002 Apr 2;21(7):1791-9. PMID: 11927563 

Yan, S., Martinez-Calvillo, S., Schnaufer, A., Sunkin, S., Myler, P.J., and Stuart, K. A low background inducible promoter system in Leishmania Donovani.  Mol. Biochem. Parasitol. 2002. 119:217-223. PMID: 11814573

Panigrahi A., Gygi S., Ernst, N., Igo, R.P., Jr., Palazzo, S.S., Schnaufer, A., Weston, D.S., Carmean, N., Salavati R., Aebersold, R., and Stuart, K. (2001) Association of two novel proteins TbMP52 and TbMP48 with the Trypanosoma brucei RNA Editing complex. Mol. Cell. Biol. 2001,21:380-389. PMID: 11134327

Panigrahi A.K., Schnaufer A., Carmean, N., Igo, R.P., Jr., Gygi S., Ernst, N., Palazzo, S.S., Weston D., Aebersold, R., Salavati R., and Stuart, K.D. Four related proteins of the T. Brucei RNA editing complex.  Mol. Cell. Biol. 2001. 21:6833-6840. PMID: 11564867

Myler PJ, Beverley SM, Cruz AK, Dobson DE, Ivens AC, McDonagh PD, Madhubala R, Martinez-Calvillo S, Ruiz JC, Saxena A, Sisk E, Sunkin SM, Worthey E, Yan S, Stuart KD. The Leishmania genome project: new insights into gene organization and function. Med Microbiol Immunol (Berl). 2001 Nov;190(1-2):9-12. PMID: 11770120

Gelb MH, Buckner FS, Yokoyama K, Ohkanda J, Hamilton AD, Nguyen L, Rossi-Bergmann B, Stuart KD, Sebti SM, Van Voorhis WC Protein prenylation in trypanosomatids: a new piggy-back medicinal chemistry target for the development of agents against tropical diseases. Farnesyl Transferase and Geranylgeranyl Transferase I: Targets for Cancer and Cardiovascular Therapy. (2001). 

Schnaufer A, Panigrahi A, Panicucci B, Igo RP Jr, Salavati R, Stuart KD. An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei. Science 291:2159-2162. 2001. PMID:  11251122

Dole V, Raj VS, Ghosh A, Madhubala R, Myler P, Stuart K. Immunization with recombinant LD1 antigens protects against experimental leishmaniasis. Vaccine 19: 423-430. 2001. PMID:  11027804

Myler PJ, Audleman L, de Vos T, Hixson G, Kiser P, Lemley C, Magness C, Rickell E, Sisk E, Sunkin S, Swartzell S, Westlake T, Bastien P, Fu G, Ivens A, Stuart K. Leishmania major Friedlin chromosome 1 has an unusual distribution of protein coding genes. PNAS 96(6):2902-2906. 1999 . PMID: 10077609

Additional Publications via PubMed (opens in new window)

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