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Leonidas Stamatatos, Ph.D.

Selected Publications

Kraft, Z*., N. R. Derby1*, R. A. McCaffrey, R. Niec, W. M. Blay, N. L. Haigwood, E. Moysi, C. J. Saunders, T. Wrin, C. J. Petropoulos, M. J. McElrath and L. Stamatatos. 2007. Macaques infected with a CCR5-tropic Simian/Human Immunodeficiency Virus develop broadly reactive anti-HIV neutralizing antibodies. J. Virol. 81; 6402-6411. PMID: 17392364

Xu, R., I.K. Srivastava, L. Kuller, I. Zarkikh, Z. Kraft, Z. Fagrouch, N. L. Letvin, J. L. Heeney, S. W. Barnett, and L. Stamatatos. 2006. Immunization with HIV-1 SF162-derived Envelope gp140 proteins does not protect macaques from heterologous simian-human immunodeficiency virus SHIV89.6P infection. Virology. 349; 276-289.  PMID: 16527321

Bolesta, E., A. Kowalczyk, A. Wierzbicki, C. Eppolito, Y. Kaneko, M. Takiguchi, L. Stamatatos, P.A. Shrikant, D. Kozbor. 2006. Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV Env glycoprotein when combined with IL21 and IL15 gene delivery. J. Immunol. 177; 177-191.   PMID: 16785513

Derby, N. R., Z. Kraft, E. Kan, E. T. Crooks, S. W. Barnett, I. K. Srivastava, J. M. Binley, and L. Stamatatos. 2006. Comparative analysis of antibody responses elicited in macaques immunized with HIV-1 SF162-derived gp140 envelope immunogens with those elicited during homologous SHIVSF162 and heterologous HIV-1 infection. J. Virol.80; 8745-8762.  PMID: 16912322

Sharma, VA., E. Kan, Y. Sun, Y. Lian, J. Cistro, V. Frasca, S. Hilt, L. Stamatatos, J. J. Donnelly, J. B. Ulmer, S. W. Barnett, and I. K. Srivastava. 2006. Structural characteristics correlate with immune responses induced by HIV envelope glycoprotein vaccines. Virology. 352; 131-144.  PMID: 16769099

Xu, R., I. K. Srivastava, C. E. Greer, I. Zarkikh, Z. Kraft, L. Kuller, J. M. Polo, S. W. Barnett, and L. Stamatatos. 2006. Characterization of immune responses elicited in macaques immunized sequentially with chimeric VEE/SIN alphavirus replicon particles expressing SIVGag and/or HIVEnv and with recombinant HIVgp140Env protein. AIDS Research and Human Retroviruses. 22; 1022-1030.  PMID: 17067273

Burke, B., N. R. Derby, Z. Kraft, C. J. Saunders, C. Dai, N. Llewellyn, I. Zharkikh, L. Vojtech, T. Zhu, I K. Srivastava, S. W. Barnett, and L. Stamatatos. 2006. Viral evolution in macaques co-infected with CCR5- and CXCR4-tropic SHIVs in the presence or absence of vaccine-elicited anti-CCR5 SHIV neutralizing antibodies. Virology. 355; 138-151.  PMID: 16920175

Gorny, M.K., L. Stamatatos, B. Volsky, K. Revesz, C. Williams, X. –H. Wang, S. Cohen, R. Staudinger, and S. Zolla-Pazner. 2005. Identification of a new quaternary neutralizing epitope on HIV-1 virus particles. J. Virol. 79; 5232- 5237. PMID: 15795308

Witvrow, M., V. Fikkert, A. Hantson, C. Pannecouque, B. R. O’Keefe, J. McMahon, L. Stamatatos, E. de Clercq, and A. Bolmstedt. 2005. Restistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A. J. Virol. 79; 7777-7784. PMID: 15919930

Saunders, C.J, R.A. McCaffrey, I. Zharkikh, Z. Kraft, S. Malembaum, B. Burke, C. Cheng-Mayer, and L. Stamatatos. 2005. The V1, V2, and V3 regions of the HIV-1 envelope differentially affect the viral phenotype in an isolate-dependent manner. J. Virol. 79; 9069-9080, PMID: 15994801

Li, M., F, Gao, J.R. Mascola, L. Stamatatos, V.R. Polonis, M. Koutsoukos, G. Voss, P. Goepfert, P. Gilbert, K.M. Greene, M. Bilska, D. L. Kothe, J.F Salazar-Gonzalez, X. Wei, J. M. Decker, B.H. Hahn, and D.C. Montefiori. 2005. Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies. J. Virol. 79; 10108-10125.  PMID: 16051804

Buckner, C., L. G. Gines, C. J. Saunders, L. Vojtech, I. Srivastava, A. Gettie, R. Bohm, J. Blanchard, S. W. Barnett, J. T. Safrit and L. Stamatatos. 2004. Priming of B anti-HIV envelope responses by vaccination is essential for the long lasting containment of viral replication in macaques infected with an R5-tropic SHIV isolate. Virology. 320; 167-180. PMID: 15003872

McCaffrey, A.R., C. Saunders, M. Hensel, and L. Stamatatos. 2004. N-linked glycosylation of the V3 loop and the immunologically silent face of gp120 protects human immunodeficiency virus type 1 SF162 from neutralization by anti-gp120 and anti-gp41 antibodies. J. Virol. 78; 3279-3295. PMID: 15016849

Haigwood, L. N. and L. Stamatatos. 2004. Role of neutralizing antibodies in HIV infection. AIDS Year in review. AIDS, 18;1-5. 

Gummuluru, S., M. Rogel, L. Stamatatos, and M. Emerman. 2003. Binding of human immunodeficiency virus type 1 to immature dendritic cells can occur independently of DC-SIGN and mannose binding C-type lectin receptors via a cholesterol dependent pathway. J. Virol. 77; 12865-12874. PMID: 14610207

Srivastava, I, K., L. Stamatatos, E. Kan, M. Vajdy, Y. Lian, S. Hilt, L. Martin, C. Vita, P. Zhu, K. H. Roux, L. Vojtech, D. Montefiori, J. Donnelly, J. B. Ulmer and S. W. Barnett. 2003. Purification, characterization and immunogenicity of a soluble trimeric envelope protein containing a partial deletion of the V2 Loop derived from SF162, an R5-tropic primary HIV-1 isolate.  J. Virol. 77; 11244-11259. PMID: 14512572

Srivastava, I., K. VanDorsten, L. Vojtech, S. W. Barnett and L. Stamatatos. 2003. Changes in the immunogenic properties of soluble gp140 HIV envelope constructs upon partial deletion of the second hypervariable region. J. Virol. 77; 2310-2320. PMID: 12551968

Srivastava, I. K., L. Stamatatos, A. Fong, H. Legg, E. Kan, S. Coates, L. Leung, M. Wininger, J. Donnelly, J. B. Ulmer and S. W. Barnett. 2002. Purifications and characterization of oligomeric envelope glycoprotein from a primary R5 subtype B human immunodeficiency virus. J. Virol. 76; 2835-2847. PMID: 11861851

Stamatatos and D. Davis. 2001. New insights into protective humoral responses and HIV vaccines. In: AIDS 2001: A year in Review. AIDS 15; S105-S115. PMID: 11816158

Barnett, S. W., S. Lu, I. Srivastava, S. Cherpelis, A. Gettie, J. Blanchard, S. Wang, I. Mboudjeka, L. Leung, Y. Lian, A. Fong, C. Buckner, A. Ly, S. Hilt, J. Ulmer, C. Wild, J. Mascola and L. Stamatatos. 2001. The ability of an oligomeric HIV-1 envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following the partial deletion of the second hypervariable region. J. Virol. 75; 5526-5540. PMID: 11356960

Cherpelis, S., I. Shrivastava, A. Gettie, X. Jin, D. D. Ho, S. W. Barnett and L. Stamatatos. 2001. DNA vaccination with the human immunodeficiency virus type 1 SF162DV2 envelope elicits immune responses that offer partial protection from simian/human immunodeficiency virus infection to CD8+ T cell-depleted rhesus macaques. J. Virol. 75; 1547-1550. PMID: 11152527

Ignatius, R., K. Mahnke, M. Rivera, K. Hong, F. Isdell, R. M. Steinman, M. Pope, and L. Stamatatos. 2000. Presentation of proteins encapsulated into sterically-stabilized liposomes by dendritic cells initiates CD8+ T cell responses in vivo. BLOOD. 96; 3505-3513.  PMID: 11071648

Ly, A and L. Stamatatos. 2000. V2 loop-glycosylation of the HIV-1SF162 envelope facilitates the interaction of this protein with the CD4 and CCR5 receptors and protects the virus from neutralization by anti-V3 loop and anti-CD4-binding site antibodies. J. Virol. 74; 6769-6776. PMID: 10888615

Stamatatos, L., M. Lim and C. Cheng-Mayer. 2000. Generation and structural analysis of soluble oligomeric envelope proteins derived from neutralization-resistant and neutralization-susceptible primary HIV-1 isolates. AIDS Res. and Hum. Retroviruses. 16; 981-994. PMID: 10890360

Stamatatos, L and C. Cheng-Mayer. 1998. An envelope modification that renders a primary, neutralization resistant, clade B HIV-1 isolate highly susceptible to neutralization by sera from other clades. J. Virol. 72;7840-7845. PMID: 9733820

Stamatatos, L., M. Wiskerchen, and C. Cheng-Mayer. 1998. Effect of major deletions in the V1 and V2 loops of a macrophage-tropic HIV-1 isolate on viral envelope structure, cell-entry and replication. AIDS Res. and Hum. Retroviruses 14;1129-1139. PMID: 9737584

Stamatatos, L. and C. Cheng-Mayer. 1995. Structural modulations of the envelope gp120 glycoprotein of HIV-1 upon oligomerization and differential V3 loop-epitope exposure of isolates displaying distinct tropism upon virion-soluble receptor binding. J. Virol. 69;6191-6198. PMID: 7545244

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