. Biography . Publications . Staff . Links  back

Marilyn Parsons , Ph.D.

Selected Publications

Karnataki, A., DeRocher, A., Coppens, I., Nash, C., Feagin, J.E., and Parsons, M.  (2007) Cell-cycle regulated targeting of an apicoplast membrane protein that lacks a canonical targeting sequence.   Mol. Micro. 63: 1653-1668. PMID: 17367386

Saveria, T., Halbach, A., Erdmann,R., Volkmer-Engert, R., Landgraf, C., Rottensteiner, H., and Parsons, M.  (2007) Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes, Eukaryotic Cell, epub ahead of print.  PMID:   17586720

Karnataki, A., DeRocher, A., Isabelle Coppens, Feagin, J.E., and Parsons, M.  (2007) A membrane protease is targeted to the relict plastid of Toxoplasma via an internal signal sequence.  Traffic, In press. 

Feagin, J.E., and Parsons, M.  (2007).  The apicoplast and mitochondrion of Toxoplasma gondii.  In:  Toxoplasma gondii, the Model Apicomplexan: Perspectives and Methods.  (K. Kim and L. Weiss, eds).  Elsevier Ltd., 207-244.    

Parsons, M., DeRocher, A., and Feagin, J.E.  Protein targeting to the apicoplast.  (2007) In:  The biology of Toxoplasma gondii (J. Ajioka and D. Soldati, eds.)  Horizon Press, in press.   

Parsons, M., Karnataki, A., Feagin, J.E., and DeRocher, A.  (2007) Protein trafficking to the apicoplast: deciphering the apicomplexan solution to secondary endosymbiosis.   Eukaryotic Cell, 6: 1081-1088.  PMID: 17513565 

Saveria, T., Kessler, P.S., Jensen, B.C., and Parsons, M.  (2007) Characterization of glycosomal RING finger proteins of trypanosomatids. Exp. Parasitol. 115: 14-24. PMID: 17188680  

Jensen, B.C.,Kifer, C.T., Brekken, D.L., Randall, A.C., Wang, Q., Drees, B.L., and Parsons, M. (2007) Characterization of Protein Kinase CK2 from Trypanosoma brucei. Mol. Biochem. Parasitol. 151: 28-40.  PMID: 17097160

Naula, C., Parsons, M., and Mottram, J.C. (2005) Protein kinases as drug targets in trypanosomes and Leishmania. Biochim. Biophys. Acta, 1754(1-2):151-9. PMID: 16198642

Parsons, M., Worthey, E.A., Ward, P.N., and Mottram, J.C. (2005) Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei, and Trypanosoma cruzi. BMC Genomics 6: 127-. PMID: 16164760

El-Sayed,N.M.A., Myler,P.J., Bartholomeu,D., Nilsson,D., Aggarwal,G., Tran,A.-N., Ghedin,E., Worthey,E.A., Delcher,A., Blandin,G., Westenberger,S., Haas,B., Caler,E., Cerqueira,G., Arner,E., Aslund,L., Bontempi,E., Branche,C., Bringaud,F., Campbell,D., Carrington,M., Crabtree,J.S., Darban,H., Edwards,K., Englund,P., Feldblyum,T., Ferella,M., Frasch,C., Kindlund,E., Klingbeil,M.M., Kluge,S., Koo,H.L., Lacerda,D., McCulloch,R., McKenna,A., Mizuno,Y., Mottram,J., Ochaya,S., Pai,G., Parsons,M., Pettersson,U., Pop,M., Luis Ramirez,J., Salzberg,S., Tammi,M., Tarleton,R.L., Teixeira,S.M., Van Aken,S., Wortman,J., Stuart,K.D., Andersson,B., Anapuma,A., Attipoe,P., Burton,P., Cadag,E., Franco da Silva,J., de Jong,P., Fazelinia,G., Gull,K., Horn,D., Hou,L., Huang,Y., Levin,M.J., Lorenzi,H., Louie,T., Machado,C.R., Nelson,S., Osoegawa,K., Pentony,M., Rinta,J., Robertson,L., Sanchez,D.O., Seyler,A., Sharma,R., Shetty,J., Simpson,A.J., Sisk,E., Vogt,C., Ward,P., Wickstead,B., White,O., Fraser,C.M., Stuart,K.D.; and Andersson,B. (2005). The genome sequence of Trypanosoma cruzi, etiological agent of Chagas' disease. Science 309: 409-415.  PMID: 15965180

Banerjee SK, Kessler PS, Saveria T, Parsons M. (2005) Identification of trypanosomatid PEX19: Functional characterization reveals impact on cell growth and glycosome size and number. Mol. Biochem. Parasitol. 142: 47-55. PMID: 15907560

Kessler, P.S., and Parsons, M. (2005) Probing the role of compartmentation of glycolysis in procyclic form Trypanosoma brucei: RNA interference studies of PEX14, hexokinase and phosphofructokinase. J. Biol. Chem., 280: 9030-9306. PMID: 15637070 

Jensen, B.C., Brekken, D.L., Randall, A.C., Kifer, C.T., and Parsons, M. (2005) Species specificity in ribosome biogenesis: a non-conserved phosphoprotein is required for 60S biogenesis in Trypanosoma brucei. Eukaryotic Cell, 4: 30-35. PMID: 15643057

DeRocher, A., Gilbert, B., Feagin, J.E., and Parsons, M. (2005). Dissection of brefeldin A sensitive and insensitive steps in apicoplast protein targeting. J. Cell Sci., 118: 565-574. PMID: 15657083

Jensen, B., Wang, Q., Kifer, C., and Parsons, M. (2003) The NOG1 GTP-binding protein is required for biogenesis of the 60S ribosomal subunit. J. Biol. Chem. 378: 32204-32211. PMID:  12788953

Furuya,T., Kessler,P., Jardim,A., Schnaufer,A., Crudder,C., and Parsons, M. (2002) Glucose is toxic to glycosome-deficient trypanosomes. Proc.Natl.Acad.Sci.U.S.A, 99:14177-82. PMID: 12386344

Pitula, J., Park, J., Parsons, M., Ruyechan, W., and Williams, N. (2002) Two families of RNA binding proteins from Trypanosoma brucei associate in a direct protein-protein interaction. Mol. Biochem. Parasitol. 122:81-89. PMID: 12076772

Park, J-H., Brekken, D., Randall, A., and Parsons, M. (2002) Molecular cloning of Trypanosoma brucei CK2 catalytic subunits: the alpha isoform is nucleolar and phosophorylates the nucleolar protein Nopp44/46. Mol. Biochem. Parasitol. 119:97-106. PMID: 11755190

Park, J-H., Jensen, B.C., Kifer, C.T., and Parsons, M. (2001) A novel nucleolar G-protein conserved in eukaryotes. J Cell Sci. 114:173-185. PMID: 11112701

Parsons, M., Furuya, T., Pal, S. and Kessler, P. (2001) Biogenesis and function of peroxisomes and glycosomes. Mol. Biochem. Parasitol. 115:19-28. PMID: 11377736

Parsons, M. and Ruben, L. (2000). Pathways involved in environmental sensing in trypanosomatids. Parasitology Today, 16:56-62. PMID: 10652488

DeRocher, A., Hagen, C.B., Froehlich, J., Feagin, J.E., and Parsons, M. (2000) Analysis of targeting sequences demonstrates that trafficking to the Toxoplasma gondii plastid branches off secretory system. J. Cell Sci. 113:3969-3977. PMID: 11058084

Manion Henderson J, Flaspohler JA, Lemley KR, Rickoll WL, Parsons M. Isolation and characterization of Leishmania mutants defective in glycosomal protein import. Mol. Biochem. Parasitol. 106:225-237. 2000. PMID: 10699252

Flaspohler JA, Lemley K, Parsons M. A dominant negative mutation in the GIM1 gene of Leishmania donovani is responsible for defects in glycosomal protein localization. Mol. Biochem. Parasitol. 98:117-128. 1999. PMID: 10215029

Brecht, M., and Parsons, M. (1998) Changes in polysome profiles accompany trypanosome development. Mol. Biochem. Parasitol. 97: 189-198. PMID: 9879897

Das A, Park JH, Hagen CB, Parsons M. Distinct domains of a nuclear protein mediate protein kinase binding interaction with nucleic acids and nuclear localization. J. Cell Sci., 111(17):2615-23. 1998. PMID: 9701560

Anderson SA, Carter V, Parsons M. Trypanosoma brucei: Molecular cloning and state-related expression of a malate dehydrogenase localized to the mitochondria.  Exp. Parasitol., 89:63-70. 1998. PMID: 9603490

Peterson GC, Sommer JM, Klosterman S, Wand CC,   Parsons M. Trypanosoma brucei: identification of an internal region of phosphoglycerate kinase required for targeting to glycosomal microbodies. Exp. Parasitol. 85(1):16-23. 1997 PMID: 9024198

Flaspohler, J.A., Rickoll, W.L., Beverley, S.M., and Parsons, M. (1997) Functional identification of a Leishmania gene related to the peroxin 2 gene reveals common ancestry of glycosomes and peroxisomes. Mol. Cell. Biol. 17:1093-1101. PMID: 9032236

Das A, Peterson GC, Kanner SB, Frevert U,   Parsons M. A major tyrosine-phosphorlated protein of Trypanosoma brucei is a nucleolar RNA-binding protein. J. Biol. Chem. 271: 15675. 1996. PMID: 8663171

Parsons M. Transfection as a tool to study organelle biogenesis in Trypanosoma brucei. Parasitol. Today 11:25. 1995.

Gale MG, Carter V, Parsons M. Translational control mediates the developmental regulation of the Trypanosoma brucei Nrk protein kinase. J. Biol. Chem. 269: 31659. 1994. PMID: 7989338

HOME | CONTACT US | SITEMAP | DONATE | POLICY

©2008 Seattle Biomedical Research Institute. All rights reserved.

SBRI is a 501(c)3 not-for-profit organization. info@sbri.org