. Biography . Publications . Staff . Links  back

Peter Myler, Ph.D.

Selected Publications

Leishmania: After The Genome. Myler PJ, and Fasel NJ (eds), Caister Academic Press, Wymondham UK, 2008 (in press).

Rosenzweig D, Smith D, Myler PJ, Olafson RW, and Zilberstein D. High throughput detection of posttranslationally modified proteins during Leishmania donovani differentiation. Proteomics 2008 (in press)

Panigrahi AK, Zíková A, Dalley RA, Acestor N, Ogata Y, Anupama A, Myler PJ, Stuart KD. Mitochondrial complexes in Trypanosoma brucei: a novel complex and a unique oxidoreductase complex. Mol Cell Proteomics 2008 (in press) PMID:18073385

Myler PJ, Searching the Tritryp genomes for drug targets in Drug Targets in Kinetoplastid Parasites, Majumder HK (ed), Landes Bio Science Publishers, Austin TX USA, 2008, 133-140.
Souza RT, Santos MR, Lima FM, El-Sayed NM, Myler PJ, Ruiz JC, da Silveira JF. New Trypanosoma cruzi repeated element that shows site specificity for insertion. Eukaryot Cell. 2007 6(7):1228-1238. PMID:17526721

Martínez-Calvillo S, Saxena A, Green A, Leland A, Myler PJ. Characterization of the RNA polymerase II and III complexes in Leishmania major. Int J Parasitol. 2007 37(5):491-502. PMID:17275824
Saxena A, Lahav T, Holland N, Aggarwal G, Anupama A, Huang Y, Volpin H, Myler PJ, Zilberstein D. Analysis of the Leishmania donovani transcriptome reveals an ordered progression of transient and permanent changes in gene expression during differentiation. Mol Biochem Parasitol. 2007 152(1):53-65. PMID:17204342

Kraemer SM, Kyes SA, Aggarwal G, Springer AL, Nelson SO, Christodoulou Z, Smith LM, Wang W, Levin E, Newbold CI, Myler PJ, Smith JD. Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum comparisons of geographically diverse isolates. BMC Genomics. 2007 8:45. PMID:17286864

Günzl A, Vanhamme L, and Myler PJ, Transcription in trypanosomes: a different means to the end in Trypanosomes: After The Genome, Barry JD, Mottram JC, McCulloch R, and Acosta-Serrano A (eds) Horizon Bioscience, Wymondham Norfolk UK, 2007, 177-208.

Cadag E, Louie B, Myler PJ, Tarczy-Hornoch P. Biomediator data integration and inference for functional annotation of anonymous sequences. Pac Symp Biocomput. 2007 343-354. PMID:17990504
Stuart KD, and Myler PJ, Comparative genomics of the trypanosomatids in Genomics and Evolution of Microbial Eukaryotes, Katz LA and Bhattacharya D (editors), Oxford University Press, Oxford UK, 2006, 155-168.

Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, Neely HM, Ross J, Earnest TN, Soltis M, Schoenfeld L, Zucker F, Merritt EA, Fan E, Verlinde CL, Hol WG. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem. 2006 5;49(20):5939-5946. PMID:17004709

Mehlin C, Boni E, Buckner FS, Engel L, Feist T, Gelb MH, Haji L, Kim D, Liu C, Mueller N, Myler PJ, Reddy JT, Sampson JN, Subramanian E, Van Voorhis WC, Worthey E, Zucker F, Hol WG. Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes. Mol Biochem Parasitol. 2006 148(2):144-160. PMID:16644028

Dobson DE, Scholtes LD, Myler PJ, Turco SJ, Beverley SM. Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications. Mol Biochem Parasitol. 2006 146(2):231-241. PMID:16464509

Robien MA, Bosch J, Buckner FS, Van Voorhis WC, Worthey EA, Myler P, Mehlin C, Boni EE, Kalyuzhniy O, Anderson L, Lauricella A, Gulde S, Luft JR, DeTitta G, Caruthers JM, Hodgson KO, Soltis M, Zucker F, Verlinde CL, Merritt EA, Schoenfeld LW, Hol WG. Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 Å resolution reveals intriguing extra electron density in the active site. Proteins. 2006 62(3):570-577. PMID:16345073

Arakaki T, Le Trong I, Phizicky E, Quartley E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Worthey E, Myler PJ, Kim D, Baker D, Hol WG, Merritt EA. Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 62(Pt 3):175-179. PMID:16511295

Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson L, Zucker F, Soltis M, Hol WG. Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum. Proteins. 2006 62(2):338-342. PMID:16304640
Padmanabhan PK, Mukherjee A, Singh S, Chattopadhyaya S, Gowri VS, Myler PJ, Srinivasan N, Madhubala R. Glyoxalase I from Leishmania donovani: a potential target for anti-parasite drug. Biochem Biophys Res Commun. 2005 337(4):1237-1248. PMID:16236261

Caruthers J, Zucker F, Worthey E, Myler PJ, Buckner F, Van Voorhuis W, Mehlin C, Boni E, Feist T, Luft J, Gulde S, Lauricella A, Kaluzhniy O, Anderson L, Le Trong I, Holmes MA, Earnest T, Soltis M, Hodgson KO, Hol WG, Merritt EA. Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci. 2005 14(11):2887-2894. PMID:16199669

Ivens AC, Peacock CS, Worthey EA, Murphy L, Aggarwal G, Berriman M, Sisk E, Rajandream MA, Adlem E, Aert R, Anupama A, Apostolou Z, Attipoe P, Bason N, Bauser C, Beck A, Beverley SM, Bianchettin G, Borzym K, Bothe G, Bruschi CV, Collins M, Cadag E, Ciarloni L, Clayton C, Coulson RM, Cronin A, Cruz AK, Davies RM, De Gaudenzi J, Dobson DE, Duesterhoeft A, Fazelina G, Fosker N, Frasch AC, Fraser A, Fuchs M, Gabel C, Goble A, Goffeau A, Harris D, Hertz-Fowler C, Hilbert H, Horn D, Huang Y, Klages S, Knights A, Kube M, Larke N, Litvin L, Lord A, Louie T, Marra M, Masuy D, Matthews K, Michaeli S, Mottram JC, Müller-Auer S, Munden H, Nelson S, Norbertczak H, Oliver K, O'neil S, Pentony M, Pohl TM, Price C, Purnelle B, Quail MA, Rabbinowitsch E, Reinhardt R, Rieger M, Rinta J, Robben J, Robertson L, Ruiz JC, Rutter S, Saunders D, Schäfer M, Schein J, Schwartz DC, Seeger K, Seyler A, Sharp S, Shin H, Sivam D, Squares R, Squares S, Tosato V, Vogt C, Volckaert G, Wambutt R, Warren T, Wedler H, Woodward J, Zhou S, Zimmermann W, Smith DF, Blackwell JM, Stuart KD, Barrell B, Myler PJ. The genome of the kinetoplastid parasite, Leishmania major. Science. 2005 309(5733):436-442. PMID:16020728

El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran AN, Ghedin E, Worthey EA, Delcher AL, Blandin G, Westenberger SJ, Caler E, Cerqueira GC, Branche C, Haas B, Anupama A, Arner E, Aslund L, Attipoe P, Bontempi E, Bringaud F, Burton P, Cadag E, Campbell DA, Carrington M, Crabtree J, Darban H, da Silveira JF, de Jong P, Edwards K, Englund PT, Fazelina G, Feldblyum T, Ferella M, Frasch AC, Gull K, Horn D, Hou L, Huang Y, Kindlund E, Klingbeil M, Kluge S,Koo H, Lacerda D, Levin MJ, Lorenzi H, Louie T, Machado CR, McCulloch R, McKenna A, Mizuno Y, Mottram JC, Nelson S, Ochaya S, Osoegawa K, Pai G, Parsons M,Pentony M, Pettersson U, Pop M, Ramirez JL, Rinta J, Robertson L, Salzberg SL, Sanchez DO, Seyler A, Sharma R, Shetty J, Simpson AJ, Sisk E, Tammi MT, Tarleton R, Teixeira S, Van Aken S, Vogt C, Ward PN, Wickstead B, Wortman J, White O, Fraser CM, Stuart KD, Andersson B. The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science. 2005 309(5733):409-415. PMID:16020725

El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, Aggarwal G, Caler E, Renauld H, Worthey EA, Hertz-Fowler C, Ghedin E, Peacock C, Bartholomeu DC, Haas BJ, Tran AN, Wortman JR, Alsmark UC, Angiuoli S, Anupama A, Badger J, Bringaud F, Cadag E, Carlton JM, Cerqueira GC, Creasy T, Delcher AL, Djikeng A, Embley TM, Hauser C, Ivens AC, Kummerfeld SK, Pereira-Leal JB, Nilsson D, Peterson J, Salzberg SL, Shallom J, Silva JC, Sundaram J, Westenberger S, White O, Melville SE, Donelson JE, Andersson B, Stuart KD, Hall N. Comparative genomics of trypanosomatid parasitic protozoa. Science. 2005 309(5733):404-409. PMID:16020724

Worthey EA, Myler PJ. Protozoan genomes: gene identification and annotation. Int J Parasitol. 2005 35(5):495-512. PMID:15826642

Martínez-Calvillo S, Stuart K, Myler PJ. Ploidy changes associated with disruption of two adjacent genes on Leishmania major chromosome 1. Int J Parasitol. 2005 35(4):419-429. PMID:15777918

Kim D, Chiurillo MA, El-Sayed N, Jones K, Santos MR, Porcile PE, Andersson B, Myler P, da Silveira JF, Ramírez JL. Telomere and subtelomere of Trypanosoma cruzi chromosomes are enriched in (pseudo)genes of retrotransposon hot spot and trans-sialidase-like gene families: the origins of T. cruzi telomeres. Gene. 2005 346:153-161. PMID:15716016

Martínez-Calvillo S, Nguyen D, Stuart K, Myler PJ. Transcription initiation and termination on Leishmania major chromosome 3. Eukaryot Cell. 2004 3(2):506-517. PMID:15075279

Martínez-Calvillo S, Yan S, Nguyen D, Fox M, Stuart K, Myler PJ. Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region. Mol Cell. 2003 11(5):1291-1299. PMID:12769852

Myler PJ, Stuart KD. Recent developments from the Leishmania genome project. Curr Opin Microbiol. 2000 3(4):412-416. PMID:10972503

Myler PJ, Audleman L, deVos T, Hixson G, Kiser P, Lemley C, Magness C, Rickel E, Sisk E, Sunkin S, Swartzell S, Westlake T, Bastien P, Fu G, Ivens A, Stuart K. Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes. Proc Natl Acad Sci U S A. 1999 96(6):2902-2906. PMID:10077609

Stuart KD, Weeks R, Guilbride L, Myler PJ. Molecular organization of Leishmania RNA virus 1. Proc Natl Acad Sci U S A. 1992 89(18):8596-600. PMID:1382295

Myler PJ, Allison J, Agabian N, Stuart K. Antigenic variation in African trypanosomes by gene replacement or activation of alternate telomeres. Cell. 1984 39(1):203-211. PMID:6091912

Myler P, Nelson RG, Agabian N, Stuart K. Two mechanisms of expression of a predominant variant antigen gene of Trypanosoma brucei. Nature. 1984 309(5965):282-284. PMID:6325951

Additional publications via PubMed

HOME | CONTACT US | SITEMAP | DONATE | POLICY

©2008 Seattle Biomedical Research Institute. All rights reserved.

SBRI is a 501(c)3 not-for-profit organization. info@sbri.org