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Helen Horton, Ph. D.

Selected Publications
Helen Horton, Evan Thomas, Jason Stucky, Ian Frank, Yunda Huang, Ya-Lin Chiu, M. Juliana McElrath^, and Stephen C. De Rosa. (2007) Optimization and Validation of an 8-Color Intracellular Cytokine Staining (ICS) Assay to Quantify Antigen-Specific T cells Induced by Vaccination. Journal of Immunological Methods 323: 39-54. PMID: 17451739

Deborah Heydenburg Fuller , Tim Shipley , Todd M. Allen, James T. Fuller, Mary S. Wu, Helen Horton, Nancy Wilson, Georg Widera, David I. Watkins. (2007) Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques. Virology 364 (2): 245-255.  PMID:  17428516

Nina D. Russell, Barney S. Graham, Michael C. Keefer, M. Juliana McElrath, Steve G. Self, Mark Deers, Kent J. Weinhold, David C. Montefiori, Guido Ferrari, Helen Horton, Georgia D. Tomaras, Sanjay Gurunathan, Lynn Baglyos, Sharon E. Frey, Mark J. Mulligan, Clayton D. Harro, Susan P. Buchbinder, Lindsey R. Baden, William A. Blattner, Beryl A. Koblin, Lawrence Corey and the NIAID HIV Vaccine Trials Network. (2007) Phase II Study of an HIV-1 Canarypox Vaccine (vCP1452), Alone and in Combination with rgp120:  Negative Results Fail to Trigger a Phase III Correlates Trial. Journal of Acquired Immunodeficiency Syndromes 44 (2) :203-12.  PMID:  17106277 

Marta Bull, Deborah Lee, Jon Hallstrom, Jason Stucky, Cassandra Beckham, Judy Gordan, Justin Penn, Ruth Baydo, Mark Deers,Ya-Lin Chiu, Abbe Rubin, Helen Horton  and M. Juliana McElrath. (2007) Defining Blood Processing Parameters for Optimal Detection of Cryopreserved Antigen-Specific Responses for HIV Vaccine Trials. Journal of Immunological Methods 322: 57-69.  PMID:  17382342

Paul A. Goepfert, Georgia Tomaras, Helen Horton, David Montefiori, Guido Ferrari, J Chiu, M Deers, G Voss, M Koutsoukos, L.Pednault, J McElrath, Paul Spearman, Jonathan D. Fuchs, Beryl A. Koblin, William A. Blattner, Sharon Frey, Lindsey R. Baden, Don Burke, Thomas Evans and the NIAID HIV Vaccine Trials Network. (2007) Durable HIV-1 Antibody and T Cell Responses Elicited by an Adjuvanted Multi-Protein Recombinant Vaccine In Uninfected Human Volunteers. Vaccine  25: 510-518.  PMID:  17049679  

Fusheng Li, Helen Horton, Peter B. Gilbert, Juliana M. McElrath, Lawrence Corey and Steve G. Self (2007) HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features. Current HIV Research. 5: 95-105.  PMID:  17266561

Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson,, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa and M. Juliana McElrath. (2006) Preservation of T Cell Proliferation Restricted by Protective HLA Alleles is Critical for Immune Control of HIV-1 Infection. Journal of Immunology. 177 (10): 7406-15.  PMID: 17082660

Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum and M. Juliana McElrath. (2006) Induction of HIV-1-Specific T Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. Journal of Virology 80(19):9779-88.  PMID: 16973582

Jie Yu, Huiyuan Chen, Helen Horton, Anju Bansal, Julie McElrath, Richard Reichman, Paul Goepfert, and Xia Jin. (2006) Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV) - and cytomegalovirus (CMV) - specific CD8+ T cell proliferation in HIV infection. Journal of Medical Virology. 78(9):1147-57.  PMID: 16847956

Paul A. Goepfert, Helen Horton, M. Juliana McElrath, Sanjay Gurunathan, Guido Ferrari, Georgia D.Tomaras, David Montefiori, Mary Allen, Ya-Lin Chiu, Paul Spearman, Jonathan D. Fuchs, Beryl A. Koblin, William A. Blattner, Sharon Frey, Michael C. Keefer, Lindsay R. Baden, Lawrence Corey, and the NIAID HIV Vaccine Trials Network. (2005) High-Dose Recombinant canarypox Vaccine Expressing HIV- 1 Protein, in Seronegative Human Subjects. Journal of Infectious Diseases 192: 1249-59.  PMID: 16136469

Holden T Maecker, Aline Rinfret, Patricia D'Souza, Janice Darden, Eva Roig, Claire Landry, Peter Hayes, Josephine Birungi, Omu Anzala, Miguel Garcia, Alexandre Harari, Ian Frank, Ruth Baydo, Megan Baker, Jennifer Holbrook, Janet Ottinger, Laurie Lamoreaux, C. Lorrie Epling, Elizabeth Sinclair, Maria A Suni, Kara Punt, Sandra Calarota, Sophia El-Bahi, Gailet Alter, Hazel Maila, Ellen Kuta, Josephine Cox, Clive Gray, Marcus Altfeld, Nolwenn Nougarede, Jean Boyer, Lynda Tussey, Timothy Tobery, Barry Bredt, Mario Roederer, Richard Koup, Vernon C Maino, Kent Weinhold, Giuseppe Pantaleo, Jill Gilmour, Helen Horton and Rafick P Sekaly. Standardization of cytokine flow cytometry assays. BMC Immunology 2005, 6:13 (24 Jun 2005)  http://www.biomedcentral.com/1471-2172/6/13.  PMID: 15978127

Josephine H Cox, Guido Ferrari, Spyros A Kalams, Wlodek Lopaczynski, Neal Oden, M. Patricia D’Souza and the ELISpot Collaborative Study Group.(2005) Results of an ELISPOT Proficiency Panel Conducted in 11 Laboratories Participating in International Human Immunodeficiency Virus Type 1 Vaccine Trials. AIDS Res Hum Retroviruses 21(1):68-81.  PMID: 15665646

Michael G Hudgens, Steven G Self, Ya-Lin Chiu, Nina D Russell, Helen Horton and M. Juliana McElrath. (2004) Statistical Considerations for the Design and Analysis of the ELISpot Assay in HIV-1 Vaccine Trials. Journal of Immunological Methods 288: 19-34. PMID: 15183082

Helen Horton, Nina Russell, Erin Moore, Ian Frank, Ruth Baydo, Colin Havenar-Daughton, Deborah Lee, Mark Deers, Michael Hudgens, Kent Weinhold and M. Juliana McElrath. (2004) Correlation of IFN-γ Secretion with Cytotoxicity in Virus-specific Memory T Cells. Journal of Infectious Diseases 190: 1692-1696 Co-first name author. PMID: 15478077

Helen Horton, Nina Russell, Michael Hudgens and M. Juliana McElrath. T Cell Immune Responses Induced by Canarypox HIV-1 Vaccines. Retroviruses of Human AIDS and Related Animal Diseases. XIIIth Cent Gardes Symposium (2002). Elsevier Press. M. Vicari, B. Dodet M. Girard, Eds.pp75-79

 Thorsten Vogel and Helen Horton , Deborah H. Fuller, Donald K. Carter, Kathy Vielhuber, David H. O’Connor, Tim Shipley, Jim Fuller, Gerd Sutter, Volker Erfle, Nancy Wilson, Louis J. Picker and David I. Watkins. (2002) Differences Between T Cell Epitopes Recognized After Immunization and After Infection. Journal of Immunology 169: 4511-4521. Co-first name author.  PMID: 12370388

Thorsten U. Vogel, Thomas C. Friedrich , David H. O’Connor , William Rehrauer, Elizabeth J. Dodds, Heather Hickman, William Hildebrand, John Sidney, Alessandro Sette, Austin Hughes, Helen Horton Kathy Vielhuber, Richard Rudersdorf, Ivna P. de Souza, Matthew R. Reynolds, Todd M. Allen, Nancy Wilson, and David I. Watkins. (2002) Escape in One of Two Cytotoxic T-Lymphocyte Epitopes Bound by a High-Frequency Major Histocompatibility Complex Class I Molecule, Mamu-A*02: a Paradigm for Virus Evolution and Persistence? Journal of Virology 76(22): 11623-11636. PMID: 12388723

Todd M. Allen, Peicheng Jing, Briana Calore, Helen Horton, David H. O’Connor, Tomas Hanke, Marian Piekarczyk, Richard Ruddersdorf, Bianca R. Mothe, Carol Emerson, Nancy Wilson, Jeffrey D. Lifson, Igor M. Belyakov, Jay A. Berzofsky, Chenxi Wang, David B. Allison, David C. Montefiori, Ronald C. Desrosiers, Steven Wolinsky, Kevin J. Kunstman, John D. Altman, Alessandro Sette, Andrew J. McMichael and David I. Watkins. (2002) Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection. Journal of Virology 76(20): 10507-10511.  PMID: 12239328

Helen Horton and Thorsten U. Vogel, Donald K. Carter, Kathy Vielhuber, Deborah H. Fuller, Tim Shipley, James T. Fuller, Kevin J. Kunstman, Gerd Sutter, David C. Montefiori, Volker Erfle, Ronald C. Desrosiers, Nancy Wilson, Louis J. Picker, Steven M. Wolinsky, Chenxi Wang, David B. Allison and David I. Watkins. (2002) Immunization of Rhesus Macaques with a DNA Prime/Modified Vaccinia Ankara Boost Regimen Induces Broad Simian Immunodeficiency Virus (SIV)-Specific T-Cell Responses and Reduces Initial Viral Replication but Does Not Prevent Disease Progression following Challenge with Pathogenic SIVmac239. Journal of Virology 76: 7187-7202.  PMID: 12072518

David H. O’Connor, Todd M. Allen, Thorsten U. Vogel, Peicheng Jing, Ivna P. DeSouza, Elizabeth Dodds, Edward J. Dunphy, Cheri Melsaether, Bianca Mothe, Hiroshi Yamamoto, Helen Horton, Nancy Wilson, Austin L. Hughes and David I. Watkins. (2002) Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection. Nature Medicine 8(5): 493-499.  PMID: 11984594

Helen Horton, Thorsten Vogel, David O’Connor, Louis Picker and David I Watkins. (2002)Analysis of the Immune Response and Viral Evolution during the Acute Phase of SIV Infection. Vaccine 20 (15): 1927-1932. PMID: 11983247

Mothe BR and Horton H, DK Carter, TM Allen, ME Liebl, P Skinner, TU Vogel, S Fuenger, Kathy Vielhuber, W Rehrauer, N Wilson, G Franchini, JD Altman, A Haase, LJ Picker, DB Allison and D Watkins. (2002) Dominance of CD8 Responses Specific for Epitopes Bound by a Single MHC Class I Molecule During the Acute Phase of Viral Infection. J.Virol. 76: 875-884. Co-first name author. PMID: 11752176

John L. Dzuris, John Sidney, Helen Horton, Rose Correa, Donald Carter, Robert W. Chesnut, David I. Watkins and Alessandro Sette. (2001) Molecular Determinants of Peptide Binding to Two Common Rhesus Macaque Major Histocompatibility Complex Class II Molecules. Journal of Virology 75: 10958-10968.  PMID: 11602736

Horton H, William Rehrauer, Elizabeth Meek, Millicent Shultz, Marian Piekarczyk, Peicheng Jing, Donald Carter, Susan R. Steffen, Briana Calore, Julie Urvater, Thorsten Vogel, Nancy Wilson, and David Watkins. (2001) Mamu-B*17- a high frequency allele which binds a CTL epitope in Nef of SIV. Immunogenetics 53 (5): 423-426.  PMID: 11486280

Evans DT, Jing P, Allen TA, O’Connor DH, Horton H, Venham JE, Piekarczyk M, Dzuris J, Dykhuzen M, Mitchen J, Rudersdorf R, Pauza CD, Sette A, Bontrop RE, DeMars R and DI Watkins. (2000) Definition of five new simian immunodeficiency virus cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: evidence for an influence on disease progression. Journal of Virology, 74: 7400-7410.  PMID: 10906193

Evans DT, O’Connor DH, Jing P, Dzuris JL, Sidney J, Da Silva J, Allen TA, Horton H, Venham JE, Rudersdorf RA, Vogel T, Pauza CD, Bontrop RE, DeMars R, Sette A, Hughes AL and DI Watkins. (1999) Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nature Medicine, 5(11): 1270-1276.  PMID: 10545993

Lobashevsky A, Smith JP, Kasten-Jolly J, Horton H, Knapp L, Bontrop RE, Watkins DI and J Thomas. (1999) Identification of DRB alleles in rhesus monkeys using polymerase chain reaction-sequence-specific primers (PCR-SSP) amplification. Tissue Antigens 54(3): 254-63.  PMID: 10519362

Horton H, Weston SD and Hewitt CRA. (1998) Allergy to antibiotics: T-cell recognition of amoxicillin is HLA-DR restricted and does not require antigen processing. Allergy; 53: 83-88.  PMID: 9491234

Hewitt CRA, Foster S, Phillips C, Horton H, Jones RM, Brown AP, Hart BJ and Pritchard DI. (1998). Mite allergens: significance of enzymatic activity. [Review] Allergy 53 (48 suppl): 60-3.  PMID: 10096811

Hewitt CRA, Horton H, Jones RM and Pritchard DI. (1997) Heterogeneous Proteolytic Specificity and Activity of the House Dust Mite Proteinase Allergen DerP1. Clinical and Experimental Allergy; 27: 201-207.PMID: 9061221

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