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Nancy Haigwood , Ph.D.

Selected Publications
Blay W, S Gnanakaran, B Foley, N Doria-Rose, BT Korber and N.L Haigwood. Consistent patterns of change during divergence of human immunodeficiency virus type 1 Envelope in SHIV-infected macaques. J Virol. 2006 Jan;80(2):999-1014. PMID: 16379001

Siman-Tov, D. D., L. Navon-Perry, N. L. Haigwood, and J. M. Gershoni. 2005. Differentiation of a passive vaccine and the humoral immune response toward infection: Analysis of phage displayed peptides. Vaccine. PMID: 16171907

Mascola, J. R., P. D'Souza, P. Gilbert, B. H. Hahn, N. L. Haigwood, L. Morris, C. J. Petropoulos, V. R. Polonis, M. Sarzotti, and D. C. Montefiori. 2005. Recommendations for the design and use of standard virus panels to assess neutralizing antibody responses elicited by candidate human immunodeficiency virus type 1 vaccines. J Virol 79:10103-7. PMID: 16051803

Mahalanabis, M., V. M. Hirsch, and N. L. Haigwood. 2005. Infection with a molecularly cloned SIVsm virus elicits high titer homologous neutralizing antibodies with heterologous neutralizing activity. J Med Primatol 34:253-61. PMID: 16128920

Doria-Rose, N. A., G. H. Learn, A. G. Rodrigo, D. C. Nickle, F. Li, M. Mahalanabis, M. T. Hensel, S. McLaughlin, P. F. Edmonson, D. Montefiori, S. W. Barnett, N. L. Haigwood, and J. I. Mullins. 2005. Human immunodeficiency virus type 1 subtype B ancestral envelope protein is functional and elicits neutralizing antibodies in rabbits similar to those elicited by a circulating subtype B envelope. J Virol 79:11214-24. PMID: 16103173

C Farquhar, R Nduati, N Haigwood, W Sutton, D Mbori-Ngacha, B Richardson, G John-Stewart, High maternal HIV-1 viral load during pregnancy is associated with reduced placental transfer of measles IgG antibody. JAIDS. PMID: 16051803

DeBerardinis P and NL Haigwood (2004) New recombinant vaccines based on the use of prokaryotic antigen-display systems. Expert Rev. Vaccines 3: 673-679. PMID: 15606352

Zhang, M., B. Gaschen, W. Blay, B. Foley, N. Haigwood, C. Kuiken, and B. Korber. 2004. Tracking global patterns of N-linked glycosylation site variation in highly variable viral glycoproteins: HIV, SIV, and HCV envelopes and influenza hemagglutinin. Glycobiology 14:1229-46. PMID: 15175256

Haigwood, N. L. 2004. Predictive value of primate models for AIDS. AIDS Rev 6:187-98. PMID: 15700617

P. Jayaraman, D. Mohan, L. Kuller, P. Polacino, N. Sheikh, H. Bielefeldt-Ohmann, B. Richardson, D. Anderson, S.-L. Hu, and NL Haigwood, (2004) Perinatal transmission of SHIV-SF162P in Macaca nemestrina. J Med Primatol 33: 243-250. PMID: 15525325

Haigwood NL, DC Montefiori, WF Sutton, J McClure, A Watson, G Voss, VM Hirsch, B Richardson, NL Letvin, S-L Hu and PR Johnson (2004) Passive immunotherapy in SIV-Infected macaques accelerates the development of neutralizing antibodies, J Virology 78: 5983-5995. PMID: 15140996

Safrit, JT, R Ruprecht, F Ferrantelli, W Xu, M Kitabwalla, K Van Rompay, M Marthas, N Haigwood, J Mascola, K Luzuriaga, S Adeniyi Jones, BJ Mathieson (2004) Immunoprophylaxis to prevent mother to child transmission. J Acqu Imm Def Syndromes 35: 169-177. PMID: 14722451

Mossman SP, C Pierce, AJ Watson, MN Robertson, JB Lynch, DC Montefiori, L Kuller, BA Richardson, JD Bradshaw, R Munn, S-L Hu, PD. Greenberg, RE Benveniste and NL Haigwood (2004) Protective immunity to SIV challenge elicited by vaccination of macaques with multigenic DNA vaccines producing virus-like particles. AIDS Res Hum Retroviruses, 20 (4) 425-434. PMID: 15157361 Haigwood, NL and L Stamatatos (2004) Role of neutralizing antibodies in HIV infection. AIDS 17: S67-S71. PMID: 15080182

N.A. Doria-Rose, C. Ohlen, P. Polacino, C.C. Pierce, M.T. Hensel, L. Kuller, S.-L. Hu, T. Mulvania, D. Anderson, P.D. Greenberg, and N.L. Haigwood. (2003) Multi-gene DNA prime-boost vaccines protect macaques from acute CD4+ T cell depletion after SHIV89.6P mucosal challenge, J Virology.

Doria-Rose N and NL Haigwood. “DNA Vaccine Strategies,” Methods, DNA Vaccination, N Sheikh and WJW Morrow, eds. 

Nishimura, Y, T Igarashi, N Haigwood, R Sadjadpour, RJ Plishka, A Buckler-White, R Shibata and MA Martin. (2002) Determination of a statistically valid neutralization titer in plasma that confers protection against SHIV challenge following passive transfer of high-titered neutralizing antibodies. J Virol 76:2123-2130. PMID: 11836389

Haigwood NL, Pierce CC, Robertson MN, Watson AJ, Montefiori DC, Rabin M, Lynch JB, Kuller L, Thompson J, Morton WR, Benveniste RE, Hu S-L, Greenberg P, Mossman SP Protection from pathogenic SIV challenge using multigenic DNA vaccines. Immunol Lett 66: 183-188. 1999.  PMID: 10593487

Shibata R, Igarashi T, Haigwood N, Buckler-White A, Ogert R, Ross W, Willey R, Cho MW, Martin MA Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys. Nature Med 5: 204-210. 1999.  PMID: 9930869

Igarashi T, Brown C, Azadegan A, Haigwood N, Martin M, Shibata R Human immunodeficiency virus type 1 neutralizing antibodies accelerate clearance of cell-free virions from blood plasma. Nature Med 5: 211-216. 1999.  PMID:9 930870

Mossman SP, CC Pierce, MN Robertson, AJ Watson, DC Montefiori, M Rabin, L Kuller, J Thompson, JB Lynch, WR Morton, RE Benveniste, R Munn, SL Hu, P Greenberg, Haigwood NL Immunization against SIVmne in macaques using multigenic DNA vaccines. J Med Primatol 28: 206-213. 1999. PMID: 10593487

Haigwood NL, Zolla-Pazner S Humoral immunity to HIV, SIV, and SHIV. AIDS 12: S121-S132. 1998  

Watson A, Ranchalis J, Travis B, McClure J, Sutton W, Johnson PR, Hu SL, Haigwood NL Plasma viremia in macaques infected with SIV: plasma viral load early in infection predicts survival. J Virol 71: 284-290. 1997. PMID:  8985348

Haigwood NL, Watson A, Sutton WF, McClure J, Lewis A, Ranchalis J, Travis B, Voss G, Letvin NL, Hu SL, Hirsch VM, Johnson PR.  Passive immune globulin therapy in the SIV/macaque model: early intervention can alter disease profile. Immunol Lett 51: 107-114. 1996.PMID:  8811353

Haigwood NL, Nara PL, Brooks E, VanNest GA, Ott G, Higgins KW, Dunlop N, Scandella CJ, Eichberg JW, Steimer KS Native but not denatured recombinant HIV-1 gp120 generates broad spectrum neutralizing antibodies in baboons. J Virol 66:172-82. 1992. PMID:  1727480

Steimer KS, Scandella CJ, Skiles PV, Haigwood NL Neutralization of divergent HIV1 isolates by conformation-dependent human antibodies to gp120. Science 254:105-08. 1991. PMID: 1718036

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