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This core provides SBRI researchers access to state-of-the-art infrastructure (hardware and software) and personnel in order to track, store, manipulate, and analyze the biological data needed for scientific testing and discovery. The facility is equipped with several multiprocessor Linux-based servers for high-capacity (multi-Gigabyte) computation, Windows-based SQL servers for database management, as well as Terabyte-scale storage capacity on the SBRI Storage Area Network. These servers host a variety of genome-scale software packages including sequence alignment and assembly, gene prediction and annotation, local BLAST service (using specialized databases), a client/server-based desktop sequence analysis package, microarray data analysis and statistical packages, and a proteomics analysis pipeline. We also provide custom designed project-specific scripts, software and GUIs. The facility is supervised by a faculty Scientific Advisor, Dr. Peter Myler, and the Director of Information Technology, Tom Blackwell. Staff includes a database specialist, bioinformatics software specialist and a bioinformatics programmer, as well as a systems administrator from the SBRI IT department. The staff works with personnel from SBRI research programs and other GHBC Core facilities to provide support for the specialized data and process management databases, data manipulation and analysis, as well as software training and consultation. Future projects include creating locally maintained organism-specific databases and software for pathogens of interest to SBRI investigators (e.g. parasites, fungi, bacteria, viruses). This would provide researchers with consistent data representation, as well as querying and retrieval tools that will support all SBRI discovery programs. To get information about Bioinformatics at SBRI, please
contact Dr. Peter Myler, (206)
256.7332.
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