Malaria Clinical Trials Center


MHCC

About HCC
cGMP Products
FAQ
HCC Staff
About HCC

About HCC

Testing Malaria Vaccines and Prophylaxis


Located within the Center for Infectious Disease Research, the Human Challenge Center is a unique, specialized facility designed to challenge human volunteers with the malaria parasite. The primary goals of the HCC are to assess the safety and efficacy of malaria vaccine candidates, including genetically attenuated whole parasite vaccines and malaria prophylaxis. The Human Challenge Center is one of only a handful of facilities of its kind in the world where sporozoites are inoculated via mosquito bite to humans under a meticulously regulated process. Here we have the ability to both manufacture malaria infected mosquitoes and deliver a controlled human malaria infection to healthy individuals in early phase trials. The HCC supports and fosters joint clinical trials for malaria vaccine and drug development by establishing and maintaining key partnerships in the community to diversify capabilities, ensure sustainability, and increase capacity. Overall, the HCC and its collaborators have conducted over 60 CHMI challenges in healthy adults, with more than 85 additional infectious mosquito-borne administrations of Plasmodium falciparum to healthy adults under experimental conditions.Volunteer here!

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cGMP Products

cGMP Clinical Insectary Facilities

Products Available for Purchase


  • Uninfected cGMP grade Anopheles stephensi mosquitoes: Live An. stephensi mosquitoes reared on site in our clinical facilities under cGMP compliance standards, avalable for purchase by cage.
  • Live, P. falciparum infected mosquitoes. Drug sensitive, characterized NF54 Plasmodium falciparum infected Anopheles stephensi mosquitoes
  • Aseptic, purified, vialed, cryopreserved, non-attenuated Plasmodium falciparum (Pf) sporozoites
  • Please contact HCC Manager for current pricing
  • For murine species of Plasmodium infected mosquitoes please click here
FAQ

FAQ


Q: What is the Malaria Clinical Trials Center?

Q: I'm interested in being a participant in a research study, how do I find out more?

Q: Are there other centers that do this sort of testing?

Q: What expertise is the Center for Infectious Disease Research using to run the facility?

Q: Is it safe to participate in malaria clinical trials?

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HCC Staff

HCC Staff

Malaria Human Challenge Center Employees


Chief Operating Officer: David Keogh

Medical Director: Sean C. Murphy, MD, PhD

Insectary Director, Director of Translational Research: Stefan Kappe, PhD

Manager, MHCC: Emma Fritzen, MS, MPH

Medical Director Seattle MCTC; FHCRC: James Kublin, MD, MPH


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