Research is the cornerstone for scientific discovery. SBRI scientists are experts in the field of research, proven by the more than 400 research projects - 48 last year alone - that provide the engine for discoveries, ranging from basic science (parasitic biology to biochemistry) to applications-based discovery (identification of malaria parasite proteins that allow it to bind placenta and cause disease in mothers and their fetuses).

Nearly each one of these projects has been published, pushing our research into the field and adding to the body of knowledge that produces applications leading to scientific and technological breakthroughs and results in real-world solutions. Since 2000, scientists at SBRI have published nearly 300 journal articles.

SBRI’s work results in breakthroughs that help people right here in Seattle, as well as on six continents around the world. Among our recent accomplishments are:

• Created a genetically attenuated (weakened) whole-organism malaria vaccine that conferred protection in a rodent model

• Established a clinical research project and lab in Morogoro, Tanzania, to study severe malaria in children

• Completed and published the genome sequences for T. cruzi, L. major and T. brucei, followed by a comparative analysis of these three parasites, as part of an international collaborative effort

• Developed novel approaches to design vaccine candidates capable of eliciting effective neutralize antibodies against HIV

• Described a novel "real time" approach for identifying and tracking tuberculosis outbreak strains

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