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Over 160 scientists, ranging from undergraduate students to postdoctoral fellows to Principal Investigators, work at SBRI, researching various facets of global infectious diseases. Each of our
18 principal investigators lead
a lab with a specific research focus.
Members
Jerry Cangelosi, Ph.D.
Dr. Cangelosi is a Principal Investigator at SBRI whose research is focused on drug resistance,
molecular epidemiology, and novel diagnostics in tuberculosis and
Mycobacterium avium complex. Before joining SBRI in 1995, he worked as a Lead Project Scientist at MicroProbe Corp. He currently is
Research Associate Professor in the Department of Pathobiology at the University of Washington. In 2002, he
initiated the Pacific Northwest Tuberculosis Straining Typing Center at SBRI, which works in conjunction with the local health department to pinpoint TB outbreaks.
Patrick Duffy, M.D.
As Director of SBRI’s Malaria Program, Dr. Duffy leads a team of scientists in both Seattle and Tanzania, who are investigating potential targets for malaria vaccines,
identifying basic mechanisms of disease and
examining more effective drug treatments against
malaria. He also directs the International Malaria Research Training Program based in Seattle and Tanzania. Prior to joining SBRI as a Principal Investigator in 2001, he
led a Research Station in Kisumu, Kenya that
conducted malaria drug and vaccines studies and
also served as Director of Preclinical Vaccine Development for the Malaria Program at Walter Reed Army Institute of Research (WRAIR).
Jean Feagin, Ph.D.
With SBRI since 1982, Dr. Feagin is now a
Principal Investigator studying organelle genome
function in malaria parasites and Toxoplasma,
and has recently initiated studies of RNA
processing in these parasites.
She is also an Associate Professor in the
Department of Pathobiology at the University of
Washington, where the graduate students voted
her the departmental teaching award in 2006. A Burroughs Wellcome Fund New
Investigator in Molecular Parasitology in 1993,
and a past member of the NIH Pathogenic
Eukaryotes Study Section (2002-2006) and of the
Molecular and Biochemical Parasitology Editorial
Board (1995-2007), Dr. Feagin currently serves
as a Specialist Editor for the International
Journal of Parasitology.
Michal Fried, Ph.D.
At SBRI since 2001, Dr. Fried became an Assistant Member in 2007. Working
closely with the laboratory of Dr. Patrick Duffy, she and her colleagues study the
development of vaccines against malaria and work
to identify disease biomarkers. Her studies form the basis of the current
effort to develop a pregnancy malaria vaccine.
Malcolm Gardner, Ph.D.
Dr. Gardner, who has researched malaria at the Walter Reed Army Institute of
Research and the Naval Medical Research Institute, came to SBRI in 2005 from The
Institute for Genomic Research (TIGR) in Maryland, where he led efforts to
sequence the genome of the human malaria parasite, P. falciparum. At
SBRI, Dr. Gardner is working in conjunction with other scientists in the Malaria
Antigen Discovery (MAD) Program to exploit the genome sequence to discover new
vaccines or drugs for malaria.
Nancy Haigwood, Ph.D.
Dr. Haigwood joined SBRI as a Principal
Investigator in 1997 and served as Director of
the Institute’s Viral Vaccines Program from
2001-2006. Her research is focused on developing
vaccines and antibody-based therapies for
HIV/AIDS. Prior to joining SBRI, Dr. Haigwood
worked for 17 years in the biotech sector,
including 10 years for Chiron Corp, where as
Director of Virology she led the preclinical
development of Chiron’s gp120 subunit HIV
vaccine. She is currently an Affiliate Member of
SBRI, with part of her laboratory located at
Oregon Health Sciences University.
Helen Horton, Ph.D.
Dr. Horton joined SBRI's Viral Vaccines Program in January 2008. She received
her Ph.D. in immunology from the University of York, UK, and comes to SBRI from
the Fred Hutchinson Cancer Research Center where she was an Associate in
Clinical Research, Program in Infectious Disease. Before joining FHRCR in 2001,
she was a researcher at the Wisconsin Regional Primate Research Center.
Stefan
Kappe, Ph.D.
Dr. Kappe joined SBRI's Malaria Program in the fall of 2003. The
focus of his research is the pre-erythrocytic
stages of malaria in the human host. Dr. Kappe
comes to SBRI from New York University where he
was an assistant professor researching blood and
liver state malaria.
Peter Myler, Ph.D.
Since joining SBRI in 1982, Dr. Myler’s research
has focused on using molecular, genomic and
bioinformatic approaches to study gene
expression in Leishmania, African
trypanosomes and Plasmodium. He is
Scientific Advisor for the DNA Sequencing,
Protein Production, and Bioinformatics Cores in
SBRI’s
Global Health and Biotechnology Center. At
the University of Washington, he is Research
Professor in the Department of Pathobiology and
the Division of Biomedical and Health
Informatics, as well as Adjunct Research
Professor in the Department of Global Health.
Marilyn Parsons, Ph.D.
With a focus on the cell biology of trypanosomes, Leishmania and Toxoplasma, Dr. Parsons has been a Principal Investigator at SBRI since 1985. She also has served as Associate Director of the Institute since 1988 and is a Professor in the Department of Pathobiology at the University of Washington. Dr. Parsons was a member of the Tropical Medicine and Parasitology Study Section of NIH
from 1994-1998. Since 2002, she has served on
the Malaria Drug Development Review Panel for
the Military Infectious Disease Research
Program. and is a member of the Faculty of 1000.
Dr. Parsons is also co-director of the
Global Infectious Diseases Training Grant
which provides research and training
opportunities in partnership between SBRI and
the University of Washington, with Jawaharlal
Nehru University and the International Center
for Genetic Engineering and Biotechnology in New
Delhi, India.
David Sherman, Ph.D.
Dr. Sherman joined SBRI as a Principal Investigator in 2007. He serves as
Director of the Institute's Tuberculosis Program. He is an Associate
Professor in the Department of Pathobiology, part of the School of Public Health
and Community Medicine at the University of Washington, a position he has held
since 2004. He has also served as Research Assistant Professor in the
Departments of Medicine and Molecular Microbiology at the Washington University
School of Medicine, St. Louis.
Arnold Smith, M.D.
Dr. Smith joined SBRI as a Principal Investigator in 2002. Prior to coming to SBRI, he served as Professor and Chair of the Department of Molecular Microbiology and Immunology at the University of Missouri School of Medicine. His work is focused on the study of
Haemophilus influenzae. During the first 10 years of his academic career, Dr. Smith worked at Harvard Medical School as part of a team that developed a vaccine to prevent
H. influenzae type b infections. He also spent 15 years researching cystic fibrosis at Children’s Hospital and Regional Medical Center in Seattle and served as an editor for the New England Journal of Medicine.
Joe Smith, Ph.D.
A Principal Investigator at SBRI since 2002, Dr. Smith’s research is a central part of SBRI’s Malaria Program, focused on developing potential targets for malaria vaccines. Prior to joining SBRI, he was an Assistant Professor in the Department of Pathology at Colorado State University. In 2000, he received the Ellison Medical Foundation New Investigator Award in Global Infectious Diseases and is currently a member of the American Association of Tropical Medicine and Hygiene.
Don Sodora, Ph.D.
Dr. Sodora joined SBRI as an Associate Member in 2007. He and his colleagues are working to
understand how HIV enters body and eventually
causes AIDS. His long-term goal is to apply the
knowledge gained from his studies to the
development of new therapies and vaccines for
HIV-infected patients. Prior to joining
the Institute, Dr. Sodora was an Assistant Professor at the University of Texas,
Southwestern Medical Center in the departments of Microbiology and Internal
Medicine.
Leonidas Stamatatos, Ph.D.
A Principal Investigator at SBRI since 2001, Dr. Stamatatos focuses on HIV vaccine development through the Institute’s Viral Vaccines Program. He served as a Staff Investigator at Aaron Diamond AIDS Research Center and as Assistant Professor at Rockefeller University in New York before joining SBRI. Currently, Dr. Stamatatos is an Associate Professor in the Department of Pathobiology at the University of Washington
and a member of the NIH Study Section, AIDS
Immunology and Pathogenesis. He is currently
leading a Vaccine Discovery Center, funded by
the Bill & Melinda Gates Foundation, focusing on
the identification of vaccines that would elicit
protective anti-HIV antibodies.
Ken Stuart, Ph.D.
Dr. Stuart, President & Director, co-founded SBRI in 1976.
He is a Professor of Pathobiology and
Microbiology at the University of Washington,
and was Chairman of Pathobiology from
1996-2004. His research is focused
on unicellular parasites that are estimated to
kill around a million people each year. His
laboratory utilizes
genomics, proteomics, and gene function
approaches to generate the knowledge that is needed in order to develop
drugs, diagnostics, and vaccines for diseases. He
serves on multiple advisory groups and received a Burroughs Wellcome Scholar in Molecular Parasitology
Award, Denis Thienpont Prize in Molecular Parasitology,
NIAID MERIT Award, and the Stoll-Stunkard Award from the American Society of Parasitologists.
Ruobing Wang, Ph.D.
A cellular immunologist, Dr. Wang has been involved in the design, production
and testing of vaccines against malaria parasites for more than 10 years, most
recently at The Institute for Genomic Research (TIGR) before joining SBRI in
2005. She has worked in the malaria program at the Naval Medical Research
Center and has extensive background in clinical trials. Dr. Wang is a
principal investigator in SBRI's Malaria Program.
Ted White, Ph.D.
Dr. White is a Principal Investigator at SBRI, where he has been researching drug resistance and virulence factors in
Candida and Aspergillus since 1996. He is also Professor in the Department of Pathobiology at the University of Washington. He received the Burroughs Wellcome Fund New Investigator Award in Molecular Pathogenic Mycology in 1997 and currently serves as Chair of
Division F (Medical Mycology) for the American
Society for Microbiology.
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