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Nearly 200 scientists, ranging from undergraduate students to postdoctoral fellows to Principal Investigators, work at SBRI, researching various facets of global infectious diseases. Each of our
15 principal investigators lead
a lab with a specific research focus.
Members
Ian Nicholas Crispe,
M.D., Ph.D.
Dr Crispe joined SBRI full time in 2009. A
member of the Malaria Research Program, he also
heads the Institute's new Infectious Disease
Immunology Initiative, adding expertise to
SBRI's infectious disease immunology work across
all program areas. He is one of the foremost
experts in liver cell immunology with
international stature in the field. His specific
interest is how immune responses develop to
foreign antigens presented in the liver, and his
current research spans liver transplantation,
hepatitis and gene therapy. Nick will strengthen
our Malaria Program's liver-stage vaccine
effort, working on the analysis of immune
responses to the liver stage and their
subversion by the parasite. Previously, he was
the Associate Director, Center for Vaccine
Biology and Immunology, and Professor of
Microbiology and Immunology and of Medicine at
the University of Rochester. Prior to joining
the University of Rochester, Nick was an
Associate Professor of Immunobiology at Yale
University. He holds a Ph.D. in immunology, as
well as an MB.BS. in medicine, from the
University of London.
Patrick Duffy, M.D.
As Director of SBRI’s Malaria Program, Dr. Duffy leads a team of scientists in both Seattle and Tanzania, who are investigating potential targets for malaria vaccines,
identifying basic mechanisms of disease and
examining more effective drug treatments against
malaria. He also directs the International Malaria Research Training Program based in Seattle and Tanzania. Prior to joining SBRI as a Principal Investigator in 2001, he
led a Research Station in Kisumu, Kenya that
conducted malaria drug and vaccines studies and
also served as Director of Preclinical Vaccine Development for the Malaria Program at Walter Reed Army Institute of Research (WRAIR).
Currently, Dr. Duffy is an Affiliate Professor
in the Department of Global Health at the
University of Washington.
Michal Fried, Ph.D.
At SBRI since 2001, Dr. Fried became an Assistant Member in 2007. Working
closely with the laboratory of Dr. Patrick Duffy, she and her colleagues study the
development of vaccines against malaria and work
to identify disease biomarkers. Her studies form the basis of the current
effort to develop a pregnancy malaria vaccine. She is an Affiliate
Associate Professor in the Department of Global Health at the University of
Washington.
Malcolm Gardner, Ph.D.
Dr. Gardner, who has researched malaria at the Walter Reed Army Institute of
Research and the Naval Medical Research Institute, came to SBRI in 2005 from The
Institute for Genomic Research (TIGR) in Maryland, where he led efforts to
sequence the genome of the human malaria parasite, P. falciparum. At
SBRI, Dr. Gardner is working in conjunction with other scientists in the Malaria
Antigen Discovery (MAD) Program to exploit the genome sequence to discover new
vaccines or drugs for malaria. He is an Affiliate Associate Professor in the
Department of Global Health at the University of Washington.
Christoph Grundner, Ph.D.
Dr. Grundner joined SBRI as Principal Investigator in 2009, and works along side
Dr. David Sherman at the Institute's tuberculosis program, which focuses on the
base biology of TB bacterium as a means to discover new drugs for the disease. Grundner's
lab is working toward a better understanding of the TB bacterium virulence by
focusing on immunity and infection. Dr. Grundner comes to SBRI from University
of California, Berkeley, where he was a postdoctoral fellow. He received his
Ph.D. from the University of Heidelberg, Germany.
Helen Horton, Ph.D.
Dr. Horton joined SBRI's Viral Vaccines Program in January 2008. She received
her Ph.D. in immunology from the University of York, UK, and comes to SBRI from
the Fred Hutchinson Cancer Research Center where she was an Associate in
Clinical Research, Program in Infectious Disease. Before joining FHRCR in 2001,
she was a researcher at the Wisconsin Regional Primate Research Center.
She is an Assistant Professor in the Department of Medicine at the University of
Washington.
Stefan
Kappe, Ph.D.
Dr. Kappe joined SBRI's Malaria Program in the fall of 2003. The
focus of his research is the pre-erythrocytic
stages of malaria in the human host, and he has
developed a genetically attenuated malaria
vaccine that will go into human trials soon. Dr. Kappe
comes to SBRI from New York University where he
was an assistant professor researching blood and
liver state malaria. He is an Affiliate
Associate Professor in the Department of Global
Health at the University of Washington.
Peter Myler, Ph.D.
Since joining SBRI in 1982, Dr. Myler’s research
has focused on using molecular, genomic and
bioinformatic approaches to study gene
expression in Leishmania, African
trypanosomes and Plasmodium. He is
Scientific Advisor for the DNA Sequencing,
Protein Production, and Bioinformatics Cores in
SBRI’s
Global Health and Biotechnology Center. At
the University of Washington, he is Research
Professor in the Division of Biomedical and Health
Informatics, as well as Adjunct Research
Professor in the Department of Global Health.
Marilyn Parsons, Ph.D.
With a focus on the cell biology of trypanosomes, Leishmania and Toxoplasma, Dr. Parsons has been a Principal Investigator at SBRI since 1985. She also has served as Associate Director of the Institute since 1988 and is a Professor in the Department of Pathobiology at the University of Washington. Dr. Parsons was a member of the Tropical Medicine and Parasitology Study Section of NIH
from 1994-1998. Since 2002, she has served on
the Malaria Drug Development Review Panel for
the Military Infectious Disease Research
Program. and is a member of the Faculty of 1000.
Dr. Parsons is also co-director of the
Global Infectious Diseases Training Grant
which provides research and training
opportunities in partnership between SBRI and
the University of Washington, with Jawaharlal
Nehru University and the International Center
for Genetic Engineering and Biotechnology in New
Delhi, India.
David Sherman, Ph.D.
Dr. Sherman joined SBRI as a Principal Investigator in 2007, and serves as
Director of the Institute's tuberculosis program, which focuses on the base
biology of TB as a means to discover new drugs for the disease. He is an
Adjunct Associate
Professor in the Department of Global Health at the University of Washington. He has also served as Research Assistant Professor in the
Departments of Medicine and Molecular Microbiology at the Washington University
School of Medicine, St. Louis.
Joe Smith, Ph.D.
A Principal Investigator at SBRI since 2002, Dr. Smith’s research is a central part of SBRI’s Malaria Program, focused on developing potential targets for malaria vaccines. Prior to joining SBRI, he was an Assistant Professor in the Department of Pathology at Colorado State University. In 2000, he received the Ellison Medical Foundation New Investigator Award in Global Infectious Diseases and is currently a member of the American Association of Tropical Medicine and Hygiene.
He is an Affiliate Associate Professor in the
Department of Global Health at the University of
Washington.
Don Sodora, Ph.D.
Dr. Sodora joined SBRI as an Associate Member in 2007. He and his colleagues are working to
understand how HIV enters body and eventually
causes AIDS. His long-term goal is to apply the
knowledge gained from his studies to the
development of new therapies and vaccines for
HIV-infected patients. Prior to joining
the Institute, Dr. Sodora was an Assistant Professor at the University of Texas,
Southwestern Medical Center in the departments of Microbiology and Internal
Medicine. He is an Affiliate Associate Professor in the Department of
Global Health at the University of Washington.
Leonidas Stamatatos, Ph.D.
A Principal Investigator at SBRI since 2001, Dr. Stamatatos focuses on HIV vaccine development through the Institute’s Viral Vaccines Program,
which he directs. He served as a Staff Investigator at Aaron Diamond AIDS Research Center and as Assistant Professor at Rockefeller University in New York before joining SBRI. Currently, Dr. Stamatatos is an
Affiliate Professor in the Department of Global
Health at the University of Washington. He is currently
leading a Vaccine Discovery Consortium, funded by
the Bill & Melinda Gates Foundation, focusing on
the identification of vaccines that would elicit
protective anti-HIV antibodies.
Ken Stuart, Ph.D.
Dr. Stuart, President & Director, founded SBRI in 1976.
He is an Affiliate Professor in the Department
of Global Health at the University of Washington,
and was Chairman of Pathobiology from
1996-2004. His research is focused
on unicellular parasites that are estimated to
kill around a million people each year. His
laboratory utilizes
genomics, proteomics, and gene function
approaches to generate the knowledge that is needed in order to develop
drugs, diagnostics, and vaccines for diseases. He
serves on multiple advisory groups and received a Burroughs Wellcome Scholar in Molecular Parasitology
Award, Denis Thienpont Prize in Molecular Parasitology,
NIAID MERIT Award, and the Stoll-Stunkard Award from the American Society of Parasitologists.
Ruobing Wang, Ph.D.
A cellular immunologist, Dr. Wang has been involved in the design, production
and testing of vaccines against malaria parasites for more than 10 years, most
recently at The Institute for Genomic Research (TIGR) before joining SBRI in
2005. She has worked in the malaria program at the Naval Medical Research
Center and has extensive background in clinical trials. Dr. Wang is a
principal investigator in SBRI's Malaria Program, and is an Affiliate Associate
Professor in the Department of Global Health at the University of Washington.
Ted White, Ph.D.
Director of SBRI's Emerging Infections Program,
Dr. White is a Principal Investigator at SBRI, where he has been researching drug resistance and virulence factors in
Candida and Aspergillus since 1996. He is also
an Affiliate Professor in the Departments of
Global Health, Microbiology and Oral Biology at the University of Washington. He received the Burroughs Wellcome Fund New Investigator Award in Molecular Pathogenic Mycology in 1997 and currently serves as Chair of
Division F (Medical Mycology) for the American
Society for Microbiology.
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